Опубликована статья: Shabalin D.A., Dvorko M.Yu., Schmidt E.Yu., Trofimov B.A. Regiocontrolled synthesis of 2,4,6-triarylpyridines from methyl ketones, electron-deficient acetylenes and ammonium acetate // Organic & Biomolecular Chemistry. – 2021. – V. 19. – Iss. 12. – P. 2703-2715. IF 3,876. Q1 (БАЦКП). 28.03.2021. DOI: 10.1039/d1ob00193k

Abstract: A novel one-pot two-step approach for the synthesis of 2,4,6-triarylpyridines via t-BuOK/DMSO-promoted C-vinylation of a variety of methyl ketones with electron-deficient acetylenes (alkynones) followed by a cyclization of the in situ generated unsaturated 1,5-dicarbonyl species with ammonium acetate has been developed. This approach possesses competitive advantages such as high regioselectivity, available starting materials and the absence of transition-metal catalysts, oxidants and undesirable byproducts. A wide synthetic utility of the developed approach was demonstrated by the synthesis of trisubstituted, tetrasubstituted and fused pyridines.

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